Prdm16 is a critical regulator of adult long-term hematopoietic stem cell quiescence
نویسندگان
چکیده
منابع مشابه
Prdm16 is a physiologic regulator of hematopoietic stem cells.
Fetal liver and adult bone marrow hematopoietic stem cells (HSCs) renew or differentiate into committed progenitors to generate all blood cells. PRDM16 is involved in human leukemic translocations and is expressed highly in some karyotypically normal acute myeloblastic leukemias. As many genes involved in leukemogenic fusions play a role in normal hematopoiesis, we analyzed the role of Prdm16 i...
متن کاملHEMATOPOIESIS AND STEM CELLS Prdm16 is a physiologic regulator of hematopoietic stem cells
Fetal liver and adult bone marrow hematopoietic stem cells (HSCs) renew or differentiate into committed progenitors to generate all blood cells. PRDM16 is involved in human leukemic translocations and is expressed highly in some karyotypically normal acute myeloblastic leukemias. As many genes involved in leukemogenic fusions play a role in normal hematopoiesis, we analyzed the role of Prdm16 i...
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The regulatory pathways necessary for the maintenance of adult hematopoietic stem cells (HSCs) remain poorly defined. By using loss-of-function approaches, we report a selective and cell-autonomous requirement for the p300/CBP-binding transcriptional coactivator Cited2 in adult HSC maintenance. Conditional deletion of Cited2 in the adult mouse results in loss of HSCs causing multilineage bone m...
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Comment on: Campaner S, et al. Cell Cycle 2013; 12;3663–72; PMID:24091730; http://dx.doi.org/10.4161/cc.26584 Senthil Raja Jayapal and Philipp Kaldis; Institute of Molecular and Cell Biology (IMCB); A*STAR (Agency for Science, Technology and Research); Singapore, Republic of Singapore; National University of Singapore (NUS); Department of Biochemistry; Singapore, Republic of Singapore; *Email: ...
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Strict regulation of stem cell metabolism is essential for tissue functions and tumor suppression. In this study, we investigated the role of fumarate hydratase (Fh1), a key component of the mitochondrial tricarboxylic acid (TCA) cycle and cytosolic fumarate metabolism, in normal and leukemic hematopoiesis. Hematopoiesis-specific Fh1 deletion (resulting in endogenous fumarate accumulation and a...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2020
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.2017626117